American Neuropsychiatric Association (ANPA)
TitleSerotonin PET Imaging in Frontotemporal Dementia
InvestigatorTiffany Chow, MD
Other InvestigatorsSandra Black, MD; Morris Freedman, MD; Paul Verhoeff, MD; Jeffrey Meyer, MD
Contact Emailtchow@rotman-baycrest.on.ca
Brief AbstractOur overall hypothesis is that serotonin 1a receptor (5HT1aR) loss is directly associated with a subset of the mood and behaviour changes observed in FTD. This study utilizes positron emission tomography (PET) neuroimaging with a radioligand for 5HT1aR. With this technology, we can take in vivo measures of 5HT1aR early in the course of illness, while the patient experiences the target neuropsychiatric symptoms. This implies the ability to associate the level of 5HT1aR loss with the severity of clinical disturbance due to FTD.
Inclusion/Exclusion CriteriaNeary criteria for FTD. Must be able to tolerate MRI scan.
Opportunities for CollaborationData on 5HT1aR may be useful for correlation with behavioral findings, response to pharmacotherapy.

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